Pediatric Differential Diagnosis

Overall Incidence

Tumor Pediatric Adult
Acute Leukemia 28% 2.3%
CNS tumors 21% 1.6%
Lymphomas 11% 4.3%
Neuroblastoma 7.5% 0%
Wilm's Tumor 6% 0%
Soft Tissue Sarcoma (RMS) 6% < 0.5%
Osteosarcoma and Ewings' 5% < 0.5%
Retinoblastoma 3% 0%
Others 12.5% > 90%

Incidence by Age

Tumor Age of Presentation
Neuroblastoma median age 2-3 years
Wilm's Tumor median age 3-4 years
Soft Tissue Sarcoma (RMS) 2-6 years old
Osteosarcoma 5-20 year of age, teens being most common
Ewings' median age 15 years
Retinoblastoma 2-4 months

Race

  • Wilms' tumor blacks > white > asian

Orbital mass

  • RMS
  • Neuroblastoma

Abdominal Mass

  • Wilm's Tumor
  • Neuroblastoma

Long bone or Pelvic bone presentation

  • half of the bone lesions are malignant

Primary Tumors

Name Frequency Age of presentation Location in bone
Osteosarcoma most common primary bone tumor 2nd Decade of life Rapidly growing bones
Ewing's Tumor 2nd most common Median age of 15 years Long bones
Pelvis
Chest Wall
Chondrosarcoma 3rd most common
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