NHL T-cell

Precursor T-Cell

• treat like ALL

Mature T-Cell: Mycosis Fungoides

Adult T-Cell Lymphoma and Leukemia

• CD2, CD3, CD5
• HTVL- genes

Clinical

• most common acute present with neoplastic cell in the blood, skin rashes, generalized lyphadenopathy, hepatosplenomegaly, and hypercalcemia.

Treatment

• Chemotherapy, monoclonal antibodies, biological agenets, and allogeneic BM transplants.

Results

• OS-5 10%

Extranodal Natural Killer T-Cell Lymphoma, Nasal Type

Definition

• Formerly Known as Angiocentric Lymphoma
• EBV+

Clinical

• presents in midfacial region and other extranodal sites
• CD2+, CD56+

Treatment

• Chemoradiation for Localized NK/T-cell lymphoma in the nasal pharynx.

Anaplastic Large Cell Lymphoma

Definition

• ALK protein is detected in 60 to 80% of the patients.

Treatment

• Just like DLBCL without rituximab thearpy.

Outcome

• ALK+ patients OS 71-93%
• ALK- paitents OS 31 to 37%.