NHL T-cell

Precursor T-Cell

  • treat like ALL

Mature T-Cell: Mycosis Fungoides

Adult T-Cell Lymphoma and Leukemia

  • CD2, CD3, CD5
  • HTVL- genes

Clinical

  • most common acute present with neoplastic cell in the blood, skin rashes, generalized lyphadenopathy, hepatosplenomegaly, and hypercalcemia.

Treatment

  • Chemotherapy, monoclonal antibodies, biological agenets, and allogeneic BM transplants.

Results

  • OS-5 10%

Extranodal Natural Killer T-Cell Lymphoma, Nasal Type

Definition

  • Formerly Known as Angiocentric Lymphoma
  • EBV+

Clinical

  • presents in midfacial region and other extranodal sites
  • CD2+, CD56+

Treatment

  • Chemoradiation for Localized NK/T-cell lymphoma in the nasal pharynx.

Anaplastic Large Cell Lymphoma

Definition

  • ALK protein is detected in 60 to 80% of the patients.

Treatment

  • Just like DLBCL without rituximab thearpy.

Outcome

  • ALK+ patients OS 71-93%
  • ALK- paitents OS 31 to 37%.
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