GYN Cervix Treatment Complications

COMPLICATIONS
Late:

  • Typically 3-5 yrs after completion of treatment
  • Fistula – 2%
  • Proctitis/cystitis – 5% for I-IIA, 10% for IIB, 15% for III
  • Vaginal stenosis – 31%
  • Hip fracture – 11% at 5 years.

Risk Factors for late complications

  • Advanced stage and volume of disease
  • Abdominal surgery
  • Osteoporosis
  • Inflammatory bowel disease
  • Concurrent chemoradiation does not have more late morbidity only acute
  • Risk Factors for Late Complication based on Eifel’s paper.
    • Hispanics less likely to suffer side-effects
    • Smoking (rectal, sm. bowel)
    • Obesity is a risk-factor for bladder complications
    • HTN (sm. bowel)
    • Very thin (BMI < 22) had increased small bowel and rectal complications
    • Pelvic inflammatory diseases, gonorrhea, and syphilis also had increased complication rates
    • Central dose > 50 Gy
Bibliography
1. Eifel PJ, Jhingran A, Bodurka DC, Levenback C, Thames H. Correlation of smoking history and other patient characteristics with major complications of pelvic radiation therapy for cervical cancer.J Clin Oncol. 2002 Sep 1;20(17):3651-7.
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