Breast Boost
Table of Contents

Local Control rates with and without 16 Gy boost. [1]

  • whole-breast irradiation of 50 Gy
  • boost dose of 16 Gy
  • a median follow-up of 10.8 years.
  • Each age group is significant (initial report was only significant for ≤ 40)
  • Worse cosmetic results with boost ==see Cosmesis==
  • 5-year local control rate: 7.3%(no boost) vs 4.3% (boost) [NEJM 345(19) November 8, 2001]
10-year local control
Age Group w/o boost wtih boost
≤ 40 23.9% 13.5%
41-50 12.5% 8.7%
51-60 7.8% 4.9%
≥ 61 7.3% 3.8%
Bibliography
1. Bartelink H, Horiot JC, Poortmans PM, et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol. 2007 Aug 1;25(22): 3259-65.
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